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The Following Telomerase info is From Wikipedia, the free encyclopedia:
Telomerase is an enzyme that adds DNA sequence repeats (“TTAGGG” in all vertebrates) to the 3′ end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. The telomeres contain condensed DNA material, giving stability to the chromosomes. The enzyme is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. The existence of a compensatory shortening of telomere (telomerase) mechanism was first predicted by Soviet biologist Alexey Olovnikov in 1973, who also suggested the Telomere hypothesis of ageing and the Telomere’s connections to cancer. Telomerase was discovered by Carol W. Greider and Elizabeth Blackburn in 1985 in the ciliate Tetrahymena. Together with Jack W. Szostak, Greider and Blackburn were awarded the 2009 Nobel Prize in Physiology or Medicine for their discovery.
|RNA-directed DNA polymerase|
|A conceptual diagram showing the protein component of telomerase (TERT) in grey and the RNA component (TR) in yellow|